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Techniques such as wet granulation, spray-drying, and hot-melt extrusion (HME) have proven effective for fabricating hybrids with acceptable flowability, compressibility, and solid-state stability [136]
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The variable weight value (VIP) in Orthogonal Partial Least Squares-Discriminant Analysis is a measure of the expression pattern of each metabolite, the explanatory ability and depth of influence on the categorical discrimination of samples in each group, to explore meaningful differential metabolites, and then use the T-test to verify whether the differential metabolites between groups are significant
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