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[Abstract]2022 Sep 6;56(17):12404-12415

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Many compounds can mop up free radicals in a test tube, but the authors argue that PCA’s value lies in its modulation of upstream regulatory pathways: by preserving SIRT1 activity and allowing Nrf2 to escape repression by its inhibitor Keap1, the compound helps the tissue rebuild its own defenses rather than merely borrowing an external one