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GSH was shown to be secreted from the liver during methionine restriction to increase blood GSH levels and increase liver cytoplasmic H 2 O 2 levels to activate Nrf2 [75,149]
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The most important pathways in KEGG enrichment pathways are lipid and atherosclerosis, hepatitis B pathways in cancer, EGFR tyrosine kinase inhibitor resistance, AGE-RAGE signaling pathway in diabetic complications, coronavirus disease-COVID-19, kaposi sarcoma-associated herpesvirus infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, toxoplasmosis, etc (Figure 8D)
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