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10.1034/j.1600-0676.2001.021004280.x 92 LiuJ.YangH

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Identical-twin concordance rates for bipolar disorder generally range from 40 to 70%, with the estimated heritability reaching as high as 90% in the most recent reports ( Not surprisingly, genetic studies have confirmed that bipolar disorder is a highly heterogeneous condition ( CACNA1C , a gene that codes for the alpha subunit of the L-type voltage-gated Ca ++ channel, has been the most often replicated finding [Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 ( CACNA1C has been associated with cognitive and attentional problems, both of which play a prominent role in bipolar psychopathology ( ODZ4 , coding for cell surface proteins involved in signaling and neuronal path finding, NCAN , a brain-expressed extracellular matrix glycoprotein (rodents with altered NCAN gene function show manic-like behaviors) and ANK3 , a gene involved in localization of sodium channels, have had replicated GWAS support ( SEC24C (involved in vesicular transportation from endoplasmic reticulum to Golgi apparatus) and MUSK (which encodes proteins responsible for receptor assembly in the neuromuscular junction) ( With the caveat that candidate gene approaches have been fast to identify risk genes for psychiatric disorders, but strikingly slow to replicate these findings when they occur, it is nonetheless of some relevance to review the most consistent findings from this approach