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This suggests to us that the ability of sulfenic acid-directed probes to report on the spatial distribution of newly oxidized proteins, some but not all of which are tethered in signaling complexes at membranes near where ROS are being produced, is also related to the transience of the SOH modification (typically being converted to disulfide bonds of some sort as they mature)

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The higher doses and costs are justified by accelerated timelines in appropriate contexts