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This May be the Result of: old age – as you age, your immunity declines physical and emotional stress – the chemicals released by your body when you’re stressed can lower your immune function HIV and AIDS – people with HIV are much more likely to get Shingles, because of their weakened immune system Bone Marrow Transplant – the conditioning you require before the transplant weakens your immune system Organ Transplant – you may need to take medication to suppress your immune system so your body accepts the donated organ Chemotherapy – chemotherapy medication, used to treat Cancer, temporarily weakens the immune system Young people who are otherwise healthy can also sometimes develop Shingles