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As shown on the right panel, aspirin irreversibly inhibits COX activity by acetylation of a serine residue in the active site for COX (SER 529 in COX-1 & SER 516 in COX-2)
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Key Mechanism Summary CagriSema's superiority over monotherapy stems from engaging two neuroanatomically distinct appetite circuits: GLP-1 agonism in the hypothalamus/NTS and amylin agonism in the area postrema
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