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Thus, with the myotendinous junction, with cause-consequence relations, the positive outcome reestablished tendon-muscle continuity supports the functional, biomechanical, microscopical, and macroscopical findings as well as eNOS and COX-2 mRNA levels, and NO- and MDA-levels in the defect formed after dissecting quadriceps tendon from the quadriceps muscle

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These early animal studies used both subcutaneous and oral administration routes, with subcutaneous delivery demonstrating greater bioavailability in pharmacokinetic assessments