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This range derives from IV human data and animal studies, not subcutaneous human pharmacokinetics
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The activated NLRP3 inflammasome not only maintains myocardial interstitial inflammatory infiltration, but its induced proinflammatory factors, such as interleukin (IL)-18 and IL-1Ξ², also activate profibrotic growth factors and promote the deposition of collagen and development of a profibrotic population of fibroblasts (46)
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