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Co-transplantation of human hepatic stem/progenitor cells (Hep) and CD34+ hemopoitic stem cells (HSCs) into transgenic mice and treatment with FKBP dimer AP20187 resulted in the construction of a novel, humanized double chimeric mouse model (AFC8-hu HSC/Hep) with a human immune system and human hepatocytes for the study of the immune pathogenesis of hepatitis C virus (HCV) (Washburn et al., 2011
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