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It reduces Cu2+ to Cu+, disrupting the GHK-Cu chelate and producing free copper ions and dehydroascorbate
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This would prevent many of the systemic side-effects of the drug and restrict its effects only to TIIs demonstrated to experience immunosuppression as a result of MAO-A activity ( Figure 1C ) ( Discussion The discovery of MAO-A as an immune checkpoint offers an exciting new pathway that can be explored for the development of novel therapies repurposing drugs developed for the regulation of neuronal serotonin signaling ( While the potential associated with the use of a multifaceted ICB therapy such as MAOIs is impressive, it is important to consider the adverse side-effects that can greatly threaten the comfort and safety of the patient
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