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Physiologically based pharmacokinetic modeling and simulation PBPK models were developed for midazolam, dextromethorphan, and mitragynine using the population-based simulator Simcyp (version 22
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LC separation, which followed the previously reported procedure 28 , was performed using a normal-phase (hydrophilic interaction chromatography, HILIC) column (ZIC-pHILIC
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