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In the methionine cycle, during the conversion of SAM to SAH, the methyl group can also be transferred to glycine to form sarcosine (dimethylglycine) via glycine N-methyltransferase (GNMT) [170]
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Since many pathologic and toxic conditions can lead to activation of CMK and phosphorylation of GCLC, inhibition of GCL may further contribute to toxicity
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