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Indeed, disorders of copper metabolism such as Menkes disease and Wilson disease, as well as diseases linked to dysfunction of copper-requiring enzymes, such as SOD1-linked amyotrophic lateral sclerosis, demonstrate the dramatic neurological consequences of altered copper homeostasis
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Compounds that bind iron, such as ciclopirox olamine (CPX), DFO, and deferiprone (DFP), inhibit ferroptosis by chelating iron ions and subsequently reducing ROS production (206, 207)
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