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The main consequence of these oxidative insults is the impairment of rheological properties, as well as the alteration of O 2 transport capacity, factors that are particularly critical in pathological conditions such as diabetes, chronic inflammation, and aging

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The factor responsible turned out to be a small copper-binding tripeptide whose endogenous concentration declines with age — from roughly 200 ng/mL at age 20 to 80 ng/mL at age 60. The 50-year research arc that followed makes GHK-Cu one of the most thoroughly characterized small peptides in the literature