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Primary Target — NNMT Enzyme The molecular target of 5-Amino 1MQ is the cytosolic enzyme nicotinamide N-methyltransferase (NNMT), a metabolic regulator highly expressed in adipose tissue, liver, and skeletal muscle — particularly in obesity and type 2 diabetes
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The clinical drug development program was halted in 2007 after the pivotal Phase IIb trial did not show statistically significant weight loss in the primary endpoint
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