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Apoptosis is triggered by radiation-induced DNA DSBs and oxidative stress, activating the p53-BAX/BAK signaling pathway, which leads to the release of cytochrome C and the activation of caspases-9 and −3
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seven of the eight people who had a recurrence during the study had elevated fecal calprotectin, while only one person who experienced a recurrence had normal fecal calprotectin (Tursi, Elisei, Picchio 2014)
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