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The two cysteine residues, at positions 6 and 14, form an intrachain disulfide bridge, so the fragment retains the looped C-terminal conformation of the intact hormone — the 'cyclic anti-obesity peptide' analysed by NMR in the original conformational study (Ogru et al., J Pept Res, 2000)

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When we do trichoscopy, they have clear androgenetic alopecia that needs medical or surgical treatment