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Skin Pigmentation and Glutathione Melanogenesis begins with the conversion of L-tyrosine to DOPA-quinone under the effect of tyrosinase enzyme (Figure 1)
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Previous research found that central injection of interferon-alpha in rats could excite the splenic sympathetic nerve, in turn suppress the cytotoxicity of natural killer cells via β-adrenergic mechanisms, indicating the key role of sympathetic in immunosuppression [52]
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