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The Phase III REDEFINE 4 trial marked the first direct comparison between leading obesity treatments: ↳ 84-week, open-label, randomized study ↳ CagriSema (cagrilintide 2.4mg + semaglutide 2.4mg) vs Tirzepatide 15mg ↳ 809 adults with obesity (BMI ≥30), mean baseline weight 114.2 kgs ↳ Primary endpoint: relative percent change in body weight at week 84 Weight loss results under efficacy estimand (AKA only the people that stayed adherent): 💉 CagriSema: 23.0% 💉 Zepbound: 25.5% Weight loss results under treatment regimen estimand (AKA everyone in the trial, regardless of adherence): 💉 CagriSema: 20.2% 💉 Zepbound: 23.6% CagriSema failed to meet non-inferiority to Zepbound in this trial