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Situations where CJC-1295 would generally be considered inappropriate or high-risk include: Active or prior cancer , given the theoretical role of elevated IGF-1 in tumor growth Diabetes or impaired glucose tolerance , because GH can worsen insulin resistance and raise blood sugar Pregnancy and breastfeeding , where there are no safety data whatsoever Children and adolescents , in whom manipulating the GH axis outside strict medical indications is inappropriate Serious cardiovascular, kidney, or liver disease , which fluid retention and metabolic shifts could aggravate Interactions to consider

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GH also stimulates muscle lipid uptake by increasing muscle lipoprotein lipase (LPL) activity (LeRoith and Yakar, 2007)