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Beyond these core elements, Nrf2 regulates a broad antioxidant network, including heme oxygenase-1 (HO-1, involved in iron recycling), NAD(P)H quinone dehydrogenase 1 (NQO1, which maintains antioxidant reduction), and enzymes involved in GSH synthesis (GCLC, GCLM) and regeneration (GSR) (32)
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