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Melatonin receptor polymorphisms (notably MTNR1B variants) are linked with impaired insulin secretion and heightened diabetes risk, suggesting receptor-level modulation of insulin homeostasis (198)
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FIGURE 7 In summary, PCs participate in T2DM pathophysiology via multiple mechanisms, such as enhancing insulin secretion, safeguarding pancreatic β-cells, optimizing mitochondrial function and insulin resistance, and regulating hepatic lipid metabolism
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