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The selenenic acid group is reduced back to a selenol by two glutathiones (GSH) which are in turn oxidized to disulfide (GSSG) and LOOH is reduced to its corresponding alcohol (LOH)
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165 However, studies in animal models reported that triptolide improved behavioral test scores, 179 suggesting gut–brain axis modulation through regulation of serotonergic and dopaminergic neurotransmission
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