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However in our opinion, the low probability of MS coincidence with another rare disease, together with the animal studies where MS is never a consideration, makes it more likely that these human examples align with an “inside-out” model (Figure 2), where a primary biochemical derangement of myelin, coupled with an immune predisposition, culminated in a MS-like phenotype
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No published human RCT has established a minimum effective or maximum tolerated dose of IGF-1 LR3 in healthy adults
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