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Given the similarities between stage 3 COVID-19 and other hypercytokinemic states, a variety of nonspecific immunosuppressive strategies have been proposed, such as glucocorticoids, hydroxychloroquine, colchicine, and other immunomodulators, as well as Janus kinase inhibitors and a number of targeted therapies directed at pivotal cytokines (Table 1)

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(2001), decreased RUBISCO activity was observed under Cd stress, and this decrease in RUBISCO activity might be due to the formation of mercaptide by Cd with thiol group of RUBISCO (Siborova, 1988)

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