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The NAD + -dependent enzyme SIRT1 deacetylates LC3 at K49 and K51 sites, enabling LC3 to interact with nucleoproteins and translocate to the cytoplasm, where it binds with autophagy factors such as ATG7, thereby promoting autophagy in skeletal muscle (Ruderman et al., 2010)
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Clinically, the translation of these mechanisms is underway
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