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This epigenetic modulation has been shown to reverse maladaptive plasticity in another neurological disorder, providing a mechanistic rationale for its potential application in tinnitus (Denk et al., 2013)
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54 In contrast to the negative effects of reprogramming T-cell lipid metabolism on antitumor immunity, the inhibition of ACAT1, a pivotal enzyme responsible for cholesterol esterification in CD8 + T cells, results in elevated cholesterol levels in the plasma membrane
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