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The sulfonamide 41 , like 23 (HA08) and 37 (HFI 419) increases spine density in primary cultures of hippocampal neurons but is unfortunately a too poor inhibitor of IRAP and is demonstrating a Ki value of 540 nM
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It has been suggested that the presence of S -lipoic acid in the racemic mixture may limit the polymerization of R -lipoic acid and enhance its bioavailability (52)
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