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What drives the aggressive growth and spread of #EsophagealSquamousCellCarcinoma? This study identifies HMGB3 as a key driver of ESCC progression by activating the TGIF2/HMGB3/TLR3/TGF-β signaling axis, promoting tumor proliferation and #metastasis while
Additionally, it also functions as a thiol buffer for various cellular proteins such as metallothioneins and thioredoxins, and as a key cofactor for numerous enzymes [3]
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