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Additionally, a PDZ domain in the protein’s COOH terminus was found to help retain the protein at the basolateral membrane (Greenough et al., 2004)

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Other authors propose that the development of ALI and alveolar damage can also occur in other types of respiratory infections, such as the influenza virus H1N1 and the respiratory syncytial virus (RSV), which also put the elderly population at greater risks [34], [35], [36] Oxidative stress in COVID-19 Oxidative stress has been implicated in the manifestation of critical illnesses, including ischemia and reperfusion injury and systemic inflammatory states