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Furthermore, periodontal-pathogenic bacteria, if aspirated into the lungs, induce the overexpression of ACE-2 in the alveoli (Sukumar and Tadepalli, 2021), which favors lung inflammation and exacerbated production of proinflammatory cytokines, generating a cytokine storm that induces the destruction of the resident tissue (Yin et al., 2021), caused by T2DM, which favors the severity of COVID-19 disease (Turk Wensveen et al., 2021)
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That is why targeting key components, such as SFRPs, WIF-1, DKK-1, APC, AXIN2, ICAT, LEF1 and Ξ²-catenin, of the Wntsignaling seems to be reasonable in cancer treatment (Aguilera et al., 2007)
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