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For example, amyloid-β accumulation in the pontine tegmental area and ventral medulla is found to follow a course similar to that of the reduction of REM sleep in APP-NLGF mice (Maezono et al., 2020), while reduced numbers of pedunculopontine tegmentum ChAT-positive neurons correlate with reduced REM sleep in Tg2576 mice (Zhang et al., 2005)
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