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Deficiency of Sptlc2 , an enzyme that catalyzes the rate-limiting step of de novo sphingolipid synthesis (i.e., condensing serine and palmitoyl coenzyme A into 3-keto-sphinganine), causes prolonged activation of mTORC1 and ER stress-induced cell death, thereby impairing the survival and proliferation of antiviral CD8 + T cells [1]
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