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Discovery of 4-Amino-8-Quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38
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Studies have found that NNMT expression gradually rises during adipocyte differentiation, and its enhanced activity promotes the differentiation of preadipocytes into mature adipocytes by depleting NAD⁺ and inhibiting the SIRT1 longevity pathway
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