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Akathisia is caused by drug-induced dopamine receptor blockade, usually in the striatum. A gut-produced peptide called BPC-157 often used for injuries has been recognised to reverse D receptor blockade, and repair dopaminergic
Perturbations in the gut microbiota expose the intestine to inflammatory and genotoxic metabolites such as secondary bile salts, trimethylamine N-oxide, hydrogen sulfide, heme, nitrosamines, heterocyclic amines, and polyaromatic hydrocarbons
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