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Previous work from our group and others revealed that ΑΑ removal inactivates mTORC1 via the lysosomal relocalization of the TSC complex, and that the TSC is necessary for proper mTORC1 inactivation and cellular response to AA starvation ( Drosophila or mammalian cells makes them partially insensitive to AA removal due to the defective recruitment of the TSC ( FIGURE 3 Follow-up work suggested that the lysosomal relocalization of TSC is not restricted to AA starvation, but is rather a universal response to cellular stresses
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