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glutathione redox stress l-Arginine induces antioxidant response to prevent oxidative via stimulation of synthesis and activation of Nrf2 pathway capsule serum glutathione G
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Notably, elevated levels of LPS in the CNS directly activate microglial TLR4, perpetuating a self-amplifying cycle of cytokine release and oxidative stress that exacerbates BBB breakdown [57, 58]
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