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This is the proposed central axis of the prosynaptic effect, discussed in the review by Wright & Harding 2015 as a key element of the mechanism of this class of Ang-IV analogs Induction of synaptogenesis — in hippocampal neuron cultures, an increase in dendritic spine density and the number of functional synapses was reported following exposure to metabolically stabilized Ang-IV analogs (McCoy et al