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After binding of LH-RH, the LH-RH receptor-LH-RH complex is coupled to G α1 protein and activates phosphotyrosine phosphatase, which dephosphorylates receptors for epidermal growth factor (EGF), blocking the signal pathways 3,6
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Maintenance therapy should not be discontinued merely because hematological parameters have normalized if the underlying cause remains irreversible
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