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(2016) noted TSH rising from 1.6 ± 0.7 to 2.3 ± 0.9 µIU/mL over six months, with concomitant declines in free T3 and T4 [58]

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Although standard therapeutic modalities, including surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy, have improved, their clinical efficacy is often compromised by drug resistance, tumor microenvironment remodeling and immune evasion (2)