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Both microbial diversity and microbial richness are significantly decreased (a process called dysbiosis) in depressed patients, and when this atypical microbiota signature is transferred to healthy, naive rats, the recipient rodents showed anxiety-like and anhedonia behaviors [88]
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Furthermore, afferent signals, including leptin from adipose tissue, insulin from the pancreas, ghrelin, and peptide YY from the gastrointestinal tract, modulate the anorexigenic centers of the hypothalamus [4]
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