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Long-term NMN administration reverses age-associated gene expression changes in peripheral tissues and enhances mitochondrial respiratory capacity in skeletal muscle Assessments of metabolic parameters in NMN-administered mice revealed significant effects of NMN to mitigate age-associated physiological decline
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The mechanism involves enhanced fatty acid oxidation, improved insulin sensitivity in skeletal muscle, and, perhaps most impressively, the browning of white adipose tissue through the ERK signaling pathway
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