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Although expression of FVIII domains in tobacco chloroplast showed induction of oral tolerance, there are significant challenges in clinical development using the tobacco system, not least being expression of full length CTB-FVIII, which is required to encompass all known T cell epitopes to cover diverse patient populations
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doi: 10.1016/j.phymed.2024.155560 37 JungJLeeSMLeeMJRyuJSSongJHLeeJEet al
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