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NADPH, derived from glucose via the PPP, is the ultimate electron donor that reduces the downstream proteins in the GSH antioxidant system
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In Contrast, the fibrinolytics, which encounter the formed clots such as plasminogen, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), and thrombin-activatable fibrinolysis inhibitor (TAFI) are downregulated in DM (Li X et al., 2021)
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