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Furthermore, higher dosage of antioxidants may yield pro-oxidant effects by exerting proglycation, disrupting cellular signaling, promoting expression of inflammatory cytokines, and endocrine disrupting activities.45 The effects of high doses of antioxidants have also been referred as anti-OS.14 Hence, one of the highlights of the current study is also the use of appropriate doses of antioxidants for desired outcomes
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