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Activated caspase-1 can cleave gasdermin D (GSDMD), triggering pyroptosis and releasing IL-1Ξ², IL-18, and ASC specks into the extracellular environment
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Furthermore, the authors reported that the MCF-7 breast cancer cell line shows an E2-dependent increase in its survival rate, which is abrogated by pre-treating them with the anti-estrogenic compounds ICI-182, 780, or raloxifene (Yu et al., 2012)
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