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RO System:With RO System
• These endogenous compounds are: • Glucuronic acid • Sulfate group • Amino acid (Glycine) • Methyl group (as SAM) • Acetyl group (as acetyl CoA) • Glutathione (tripeptide) Glutathione Methyl source Sulfate Glucuronic acid Acetyl CoA Glycine Phase-II Drug Metabolism • Involves the following conjugation reactions that are catalyzed by transferase enzymes: • Glucuronidation
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