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While a full discussion of the tumor microenvironment, and in particular the role of the innate and adaptive immune system, is beyond the scope of this review, we highlight several features of the stromal microenvironment that can facilitate the survival of drug-tolerant cells by modulating tumor intrinsic survival pathways

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This design encapsulates the antitumor drug methotrexate (MTX) within the MOF nanoparticle pores while trapping collagenase in the mesoporous cavities between particles