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229,285 To create a tool for further investigation of its function, SHP2 was caged with NPY at Y279, a residue in the key KNRY motif of SHP2 that is responsible for phosphotyrosine recognition and stabilization through stacking interactions with the aromatic ring of the substrate
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24,25,188–190 Current pharmacologic options for managing PPI-refractory GERD are also limited
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